This comprehensive course integrates principles of orthopedic biomechanics with bone modeling techniques and orthopedic implant design. Students will explore the intricate biomechanics of bones, joints, and musculoskeletal structures, alongside learning practical skills for creating precise CAD models of bone structures and orthopedic implants. Understanding the mechanical properties of the musculoskeletal system and the principles of CAD modeling is crucial in various fields, including orthopedics, biomechanics, and medical research. Through a blend of theoretical knowledge and hands-on activities, students will gain a deep understanding of orthopedic biomechanics, modeling technologies, and implant design principles. The course begins with an in-depth examination of bone anatomy, covering topics such as bone composition, microstructure, and biomechanics. Students will learn about the different types of bones and their functions. Special emphasis will be placed on distinguishing between healthy and diseased bone, including common pathologies such as fractures, osteoporosis, and bone tumors. Building upon this foundation, students will delve into the process of bone segmentation from CT scans. They will learn the principles of CT imaging and how to navigate and interpret CT datasets effectively. Through hands-on exercises and practical demonstrations, students will explore various image segmentation techniques to isolate bone structures from surrounding tissues and artifacts. Using 3D Slicer, an industry-standard software tool, students will gain proficiency in segmenting CT images to generate accurate outlines of bones. With a solid understanding of bone anatomy and segmentation techniques in place, students will then transition to CAD modeling. They will learn to convert segmented CT images into precise 3D CAD models. They will also explore orthopedic implant design principles, applying their knowledge to create fracture fixation devices such as plates, screws, and nails. Furthermore, they will learn about various methods and applications for custom-made orthopedic implants which can enhance patient outcomes, reduce complications, and improve quality of life across a wide range of orthopedic conditions and surgical procedures. Throughout the course, students will engage in a practical project and case studies aimed at applying their knowledge and skills to real-world scenarios. This course provides students with the necessary knowledge and skills to address real-world challenges in orthopedic research, device design, and patient care, preparing them for careers in orthopedic engineering, biomechanics research, and medical device manufacturing.