Does artificial life hold the same weight as natural life? What is the ‘human’ in a world of genome manipulation and synthetic creation? Focusing on the multiple life forms produced and augmented in Bioart, this course surveys collaborative projects between art and science/technology, and their historical landscapes. The goal of this course is to reconsider the meaning of ‘artificiality’ in the aesthetic, technological, political, and economic spheres that make up our shared ecosystem. We will be looking into the development of new technologies and protocols concerning the manipulation of life, and how artists have responded to the social, political, and ethical issues involved. We will endeavor to explore multiple artworks beginning from the 1990s, within various cultural infrastructures such as: science labs, agricultural and medical corporations, and biomaterial banks, with an emphasis on how they each transform our conceptions about what it means to be a living thing. Each week, selected readings will be covered and connected to the following themes: artificial life, semi-living, and anti-life. Within these themes, we will be discussing how Bioart interprets the gravity and complexities around genetic engineering (CRISPR, Human Genome Project), hybrid networks (collaborations, regulations, funding, markets, institutions), and chimeric identities, and how all of these reconstruct our subjective experiences. Through this course, students will better understand the contemporary anxiety surrounding synthetic genome architecture and our shared ethical responsibilities in the face of technological manipulation.